Understanding how certain proteins affect female germ cell development
Official title: ERK-mediated regulation of RNA binding protein condensation during female germ cell development
Funded at Central Michigan University · NIH-10799122 · Data updated 2026-11-12
This study is looking at how certain proteins help develop the cells that turn into eggs, which is important for fertility and healthy pregnancies, to better understand why some women have trouble getting pregnant or have babies with birth defects.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $100,000 |
| NIH project number | 3R15GM147844-01S1 |
| Project ID | NIH-10799122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility or those with a history of birth defects in their families.
✕Less likely to help
Patients who are not female or those who do not have concerns related to fertility or congenital abnormalities may not benefit from this research.
What this research studies
This research investigates the role of specific proteins in the development of female germ cells, which are crucial for fertility and preventing birth defects. The study focuses on how these proteins interact and form structures that regulate the growth of oocytes, the cells that develop into eggs. By examining the mechanisms that control these interactions, the research aims to uncover why some women experience infertility or give birth to children with congenital abnormalities. The approach involves analyzing cellular processes in the ovaries to identify key regulatory pathways.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing infertility and congenital defects in future generations.
How similar studies have gone: While the specific mechanisms being studied are novel, related research has shown promise in understanding protein interactions in cellular development.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Schisa, Jennifer — Central Michigan University
- Study coordinator: Schisa, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.