Understanding how certain proteins affect fat and cholesterol levels in the body
Post-translational Control of Triglyceride and Cholesterol Metabolism by ANGPTL3 & ANGPTL8 in ApoBCL Clearance
This study is looking at how two proteins, ANGPTL3 and ANGPTL8, affect fat and cholesterol levels in the blood, which could help find new ways to treat heart and metabolic issues for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11004400 on NIH RePORTER |
What this research studies
This research investigates the roles of proteins ANGPTL3 and ANGPTL8 in regulating triglyceride and cholesterol metabolism. By studying how these proteins interact and inhibit an enzyme called lipoprotein lipase, the research aims to uncover mechanisms that lower fat levels in the blood. The team will explore the effects of inactivating these proteins and how this can lead to reduced cholesterol and triglyceride levels, potentially offering new treatment strategies for cardiometabolic disorders. Patients may benefit from insights that could lead to innovative therapies for managing cholesterol and triglyceride levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with high triglyceride or cholesterol levels, particularly those at risk for cardiometabolic diseases.
Not a fit: Patients with normal triglyceride and cholesterol levels may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for lowering cholesterol and triglyceride levels, improving heart health.
How similar studies have performed: Previous research has shown that inactivating ANGPTL3 can effectively lower triglyceride levels, indicating a promising avenue for further exploration.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Hobbs, Helen Haskell — Ut Southwestern Medical Center
- Study coordinator: Hobbs, Helen Haskell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.