Understanding how certain proteins affect facial development in mammals
Official title: Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery
Funded at University of California, San Francisco · NIH-11056662 · Data updated 2026-11-12
This study is looking at how certain genes affect the development of facial features in mice, which could help us understand and find ways to prevent or treat conditions like cleft palate in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 16, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $452,681 |
| NIH project number | 1R01DE033885-01A1 |
| Project ID | NIH-11056662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital craniofacial abnormalities or those at risk of developing such conditions.
✕Less likely to help
Patients with craniofacial conditions unrelated to genetic or developmental signaling pathways may not benefit from this research.
What this research studies
This research investigates the role of the ESCRT machinery in the development of craniofacial structures in mammals. By studying a specific mouse model with a mutation in the ESCRT-II-encoding gene Vps25, researchers aim to understand how disruptions in cellular signaling and trafficking can lead to craniofacial defects. The study involves examining gene expression patterns and the effects of signaling pathways on craniofacial development, which could provide insights into congenital abnormalities such as cleft palate. The findings may help identify potential therapeutic targets for preventing or treating these birth defects.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating craniofacial birth defects in humans.
How similar studies have gone: Previous research has shown success in understanding the role of genetic factors in craniofacial development, making this approach promising.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Selleri, Licia — University of California, San Francisco
- Study coordinator: Selleri, Licia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.