Understanding how certain proteins affect facial development and function.
Investigating craniofacial phenotypes, cellular function, and membrane biochemistry of ciliary proteins Rsg1 and the Fam92-Chibby-Dzip module
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10914661
This study is looking at how certain proteins might affect the development of facial features, which could help us understand and improve treatments for people with facial differences from birth.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10914661 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins, Rsg1 and the Fam92-Chibby-Dzip module, in the development of craniofacial structures. By using animal models, the study will explore how disruptions in these proteins can lead to congenital facial differences. Researchers will utilize live imaging techniques to observe the cellular functions of these proteins in real-time, as well as biochemical assays to understand their roles in cell membrane structure. The goal is to gain insights into the mechanisms behind craniofacial disorders, potentially leading to better understanding and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital craniofacial disorders or those with a family history of such conditions.
Not a fit: Patients without craniofacial disorders or those unrelated to the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the causes of congenital craniofacial disorders, leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: Previous research has shown success in understanding the role of ciliary proteins in other developmental disorders, suggesting a promising avenue for this investigation.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAZQUEZ, NEFTALI — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: VAZQUEZ, NEFTALI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.