Understanding how certain proteins affect egg development and fertility
Official title: ERK-mediated regulation of RNA binding protein condensation during female germ cell development
Funded at Central Michigan University · NIH-10514951 · Data updated 2026-11-12
This study is looking at how certain proteins help control the growth of eggs and early embryos, which is important for preventing infertility and birth defects, and it aims to understand how a specific signaling pathway affects these proteins to keep eggs healthy.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $425,395 |
| NIH project number | 1R15GM147844-01 |
| Project ID | NIH-10514951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility or those at risk of primary ovarian insufficiency.
✕Less likely to help
Patients who are not experiencing fertility issues or do not have a history of ovarian dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate maternal mRNAs essential for the growth of eggs and early embryonic development. It focuses on how specific proteins, known as RNA binding proteins, behave during the development of female germ cells and how their improper regulation can lead to infertility and birth defects. The study aims to uncover the role of the ERK signaling pathway in controlling these proteins and their phase separation, which is crucial for maintaining egg quality. By using experimental approaches, the research seeks to identify the molecular processes that ensure proper egg development.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating infertility and preventing birth defects.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding the role of RNA binding proteins in fertility.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Schisa, Jennifer — Central Michigan University
- Study coordinator: Schisa, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.