Understanding how certain proteins affect DNA repair processes
Official title: Admin Core: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
Funded at University of Texas Hlth Science Center · NIH-10847787 · Data updated 2026-11-12
This study is looking at how certain proteins linked to the BRCA genes help our cells fix damaged DNA, which is important for keeping us healthy and preventing cancer, and it hopes to find ways to improve these repair processes for better cancer prevention.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $98,044 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of breast or ovarian cancer, particularly those with mutations in the BRCA1 or BRCA2 genes.
✕Less likely to help
Patients without a genetic predisposition to breast or ovarian cancer or those who do not have a significant family history of these cancers may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific proteins, particularly those related to the BRCA genes, regulate the repair of DNA damage in cells. It focuses on understanding how these proteins influence the choice between different DNA repair pathways, which is crucial for maintaining genome stability. By collaborating with multiple laboratories, the project aims to uncover the intricate details of DNA repair processes and how they can be manipulated to prevent cancer development. Patients may benefit from insights gained into how to improve DNA repair mechanisms, potentially leading to better cancer prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cancer by enhancing DNA repair mechanisms.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, particularly in relation to BRCA mutations, indicating that this approach has a solid foundation.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Sung, Patrick — University of Texas Hlth Science Center
- Study coordinator: Sung, Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.