Understanding how certain proteins affect damage after spinal cord injuries
Role of the pro-inflammatory cytokines IL-12 and IL-23 in secondary damage after spinal cord injury
['FUNDING_OTHER'] · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · NIH-10951514
This study is looking at how a protein called IL-12 might make things worse after a spinal cord injury by causing inflammation and damage, and it hopes to find ways to help improve treatment for people with these injuries.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEMENT J. ZABLOCKI VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10951514 on ClinicalTrials.gov |
What this research studies
This research investigates the role of pro-inflammatory cytokines, specifically IL-12, in causing further damage after spinal cord injuries (SCI). It aims to understand how these proteins contribute to inflammation and tissue loss, which can worsen the condition of patients. The study will explore the mechanisms by which IL-12 affects astrocytes, a type of brain cell, and how this signaling can lead to both harmful and beneficial immune responses. By identifying these processes, the research seeks to inform future treatments that could mitigate secondary damage following SCI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a spinal cord injury and are dealing with the consequences of inflammation and tissue damage.
Not a fit: Patients who have not suffered a spinal cord injury or those with chronic conditions unrelated to inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce inflammation and improve recovery outcomes for patients with spinal cord injuries.
How similar studies have performed: Previous research has indicated that targeting inflammatory responses can improve outcomes in spinal cord injury, suggesting that this approach may yield beneficial results.
Where this research is happening
MILWAUKEE, UNITED STATES
- CLEMENT J. ZABLOCKI VA MEDICAL CENTER — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWARTZ, KARIN — CLEMENT J. ZABLOCKI VA MEDICAL CENTER
- Study coordinator: SWARTZ, KARIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.