Understanding how certain proteins affect chromosome stability in triple-negative breast cancer
Robust-to-fragile transitions of a phase-separated mitotic organelle in triple-negative breast cancer
This study is looking at how having the wrong number of chromosomes in cells might affect triple-negative breast cancer, focusing on certain proteins that could help us find new ways to treat this tough type of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10903894 on NIH RePORTER |
What this research studies
This research investigates the role of aneuploidy, a condition where cells have an abnormal number of chromosomes, in triple-negative breast cancer. It focuses on how specific proteins, particularly those involved in the chromosome passenger complex, behave during cell division and how their dysfunction can lead to cancer progression. By examining the molecular mechanisms that contribute to chromosome instability, the research aims to identify potential targets for therapeutic intervention. Patients may benefit from insights that could lead to new treatment strategies for this aggressive form of breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer, particularly those exhibiting chromosomal abnormalities.
Not a fit: Patients with other types of breast cancer or those without chromosomal instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve outcomes for patients with triple-negative breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromosomal abnormalities in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Stukenberg, P. Todd — University of Virginia
- Study coordinator: Stukenberg, P. Todd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.