Understanding how certain proteins affect cell organelles and microtubules during development
Common Regulatory Pathways for the Genesis of Lysosome-Related Organelles and Dynamics of Microtubules during Development
['FUNDING_R01'] · CALIFORNIA INSTITUTE OF TECHNOLOGY · NIH-10908302
This study is looking at how a protein called LYST affects tiny structures in our cells that help with important functions, especially in people with Chediak-Higashi Syndrome, to better understand how changes in this protein can lead to problems in cell development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CALIFORNIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (PASADENA, UNITED STATES) |
| Trial ID | NIH-10908302 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the LYST protein in the formation and function of lysosome-related organelles (LROs) and their interaction with microtubules during cell development. Using a Drosophila model, the study aims to clarify how mutations in the LYST gene, which are linked to Chediak-Higashi Syndrome, impact the size and dynamics of these organelles. By examining the behavior of microtubules and centrosomes, the research seeks to uncover the underlying mechanisms that contribute to cellular defects observed in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chediak-Higashi Syndrome or those with related genetic mutations affecting lysosomal function.
Not a fit: Patients without genetic mutations related to lysosomal trafficking or those not affected by Chediak-Higashi Syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Chediak-Higashi Syndrome and potential therapeutic strategies to address its cellular defects.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal function and microtubule dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
PASADENA, UNITED STATES
- CALIFORNIA INSTITUTE OF TECHNOLOGY — PASADENA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLOVER, DAVID M — CALIFORNIA INSTITUTE OF TECHNOLOGY
- Study coordinator: GLOVER, DAVID M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.