Understanding how certain proteins affect cell health and disease
Biochemistry, biology and diversity of Fic domains
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10766685
This study is looking at how certain proteins help cells handle stress and how problems with these proteins might lead to diseases like cancer and brain disorders, with the hope that this research can lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10766685 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Fic domains in cellular processes, particularly focusing on how they regulate a protein called BiP during stress conditions in cells. By studying these mechanisms, the research aims to uncover how disruptions in these processes can lead to diseases such as cancer and neurodegenerative disorders. The approach involves both laboratory experiments and studies in living organisms to explore the biochemical interactions and effects of Fic proteins. Patients may benefit from insights gained into how these proteins can be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancer or neurodegenerative diseases, particularly those with conditions linked to cellular stress responses.
Not a fit: Patients with conditions unrelated to cellular stress or those not experiencing cancer or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancer and neurodegenerative diseases by targeting the mechanisms that regulate cell health.
How similar studies have performed: Other research has shown promising results in understanding the role of protein regulation in diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORTH, KIM — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ORTH, KIM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.