Understanding how certain proteins affect cancer growth and treatment resistance in colorectal cancer
Regulation of RBP Function during EMT
This study is looking at how certain proteins affect colorectal cancer, especially how they help cancer cells grow and become tougher against treatments, with the hope of finding better ways to target and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11081804 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in colorectal cancer, particularly focusing on how they influence tumor initiation and the transition of cancer cells to a more aggressive state. By studying tumor initiating cells (TICs), which are known to contribute to drug resistance, the research aims to uncover the mechanisms that allow these cells to survive and proliferate. The team will utilize advanced techniques to analyze gene interactions and protein functions, which could lead to new insights into how to effectively target and treat colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with KRAS mutations.
Not a fit: Patients with non-colorectal cancers or those without KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colorectal cancer by targeting the mechanisms that drive tumor growth and resistance.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Lewis, Robert E. — University of Nebraska Medical Center
- Study coordinator: Lewis, Robert E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.