Understanding how certain proteins affect cancer cell behavior
Deciphering molecular mechanisms of Epithelial Plasticity
This study is looking at how certain proteins help cancer cells grow and resist treatment, especially in tough cases like pancreatic cancer, to find new ways to improve care for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10986113 on NIH RePORTER |
What this research studies
This research investigates the role of cellular plasticity, particularly the process known as epithelial-to-mesenchymal transition (EMT), in cancer progression and treatment resistance. It focuses on how specific proteins, such as AXL and AKT3, contribute to the survival and spread of cancer cells, especially in aggressive forms like pancreatic cancer. By exploring the molecular mechanisms involved, the research aims to identify potential targets for new cancer therapies that could improve patient outcomes. Patients may benefit from insights gained into how their tumors behave and respond to treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with high-grade cancers, particularly those with pancreatic ductal adenocarcinoma or other cancers exhibiting EMT characteristics.
Not a fit: Patients with early-stage, low-grade cancers or those not exhibiting EMT features may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve treatment effectiveness for patients with aggressive cancers.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Baker, Emily Arner — Vanderbilt University Medical Center
- Study coordinator: Baker, Emily Arner
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.