Understanding how certain proteins affect brain health and disease
Discovering How Cu(II)/Zn(II) Uptake by the Prion Protein Controls Structure, Function and Neurotoxicity
This study is looking at how a protein in our cells interacts with metals like copper and zinc, and how this might affect brain health in people with Alzheimer's disease, with the hope of finding new ways to help treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-11064055 on NIH RePORTER |
What this research studies
This research investigates the role of the cellular prion protein (PrPC) in neurodegenerative diseases, particularly Alzheimer's disease. It focuses on how PrPC interacts with copper and zinc ions and how these interactions influence neurotoxicity and the transport of harmful amyloid beta peptides into cells. By exploring the biochemical pathways involved, the research aims to uncover new mechanisms that contribute to neuron stress and dysfunction. Patients may benefit from insights gained into the molecular processes underlying Alzheimer's disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases unrelated to prion proteins or Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate neurotoxicity and improve outcomes for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of prion proteins in neurodegeneration, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Millhauser, Glenn L — University of California Santa Cruz
- Study coordinator: Millhauser, Glenn L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.