Understanding how certain proteins affect brain cell survival and connections.
Clustered protocadherin regulation of cortical interneuron survival circuit assembly and plasticity
This study is looking at how certain proteins help brain cells called cortical interneurons grow and work together, which could lead to better understanding of brain health and help with conditions that affect thinking and learning.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10916418 on NIH RePORTER |
What this research studies
This research investigates the role of clustered protocadherins in the survival and assembly of cortical interneurons, which are crucial for brain function. By utilizing advanced techniques such as 2-photon imaging, the study aims to explore how these proteins influence the development and plasticity of neural circuits. Patients may benefit from insights gained about brain cell interactions and their implications for cognitive health and neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may be experiencing cognitive dysfunction or related neurological issues.
Not a fit: Patients with acute neurological injuries or those under 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain health and treating neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of cell adhesion molecules in brain function, indicating potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Alvarez-Buylla, Arturo — University of California, San Francisco
- Study coordinator: Alvarez-Buylla, Arturo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.