Understanding how certain proteins affect brain cell division and cancer development
Official title: Elucidating the mechanisms of Orb2 mediated neural stem cell asymmetry and division
Funded at Emory University · NIH-10910874 · Data updated 2026-11-12
This study is looking at how a protein called Orb2 affects the way brain stem cells divide and grow, using fruit flies to help understand how problems in this process might lead to brain cancer, with the hope of finding better treatments in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS134380-02 |
| Project ID | NIH-10910874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with high-grade brain cancers that exhibit centrosome amplification.
✕Less likely to help
Patients with brain cancers that do not involve centrosome abnormalities or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of the Orb2 protein in neural stem cells, particularly how it influences the division and asymmetry of these cells. By using Drosophila as a model organism, the study aims to uncover the mechanisms that lead to centrosome amplification, which is often linked to poor outcomes in brain cancer. The researchers will explore how disruptions in cell division processes contribute to tumorigenesis, providing insights that could inform future cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating brain cancers by targeting the mechanisms of cell division and centrosome regulation.
How similar studies have gone: Previous research has shown that understanding centrosome dynamics in model organisms can lead to significant insights into cancer biology, suggesting a promising avenue for this investigation.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Buehler, Joseph — Emory University
- Study coordinator: Buehler, Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.