Understanding how certain proteins affect blood vessel function and adaptation.
Role of endothelial Sox17 in EC-SMC crosstalk and homeostatic regulation of blood vessel adaption to arterial hemodynamics
This study is looking at how certain proteins, especially Sox17, help blood vessel cells talk to each other, which could lead to better ways to treat blood vessel diseases and improve healing in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11093929 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins, particularly Sox17, in the communication between endothelial cells (which line blood vessels) and smooth muscle cells. By examining the differences between arterial and venous endothelial cells, the study aims to uncover how these proteins influence blood vessel structure and function in adults. The researchers will use advanced techniques to manipulate the expression of these proteins and observe the resulting changes in cell behavior and blood vessel adaptation. This could lead to new insights into treating vascular diseases and improving tissue engineering applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with vascular disorders or those who may benefit from blood vessel grafts.
Not a fit: Patients with non-vascular related conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vascular diseases and better outcomes for patients requiring blood vessel grafts.
How similar studies have performed: Other research has shown promise in understanding the role of transcription factors in vascular biology, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Dai, Guohao — Northeastern University
- Study coordinator: Dai, Guohao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.