Understanding how certain proteins affect blood cell behavior in sickle cell disease
Thiol isomerases and ERO1 alpha in sickle cell vaso-occlusion
This study is looking at how certain proteins affect the behavior of blood cells during painful blockages in blood flow caused by sickle cell disease, with the hope of finding new ways to help patients feel better and reduce their pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10426216 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in the behavior of blood cells during vaso-occlusion, a painful and dangerous complication of sickle cell disease. By examining how neutrophils, a type of white blood cell, interact with blood vessel walls, the study aims to uncover new therapeutic targets to improve treatment options for patients. The research employs a combination of biochemical, cellular, and animal model studies to explore the mechanisms behind these interactions. Ultimately, the goal is to develop novel therapies that can alleviate the severe pain and complications associated with sickle cell disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease, particularly those experiencing frequent vaso-occlusive crises.
Not a fit: Patients with other forms of anemia or blood disorders unrelated to sickle cell disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce pain crises and other complications for patients with sickle cell disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of blood cell interactions in sickle cell disease, suggesting that this approach could lead to meaningful advancements.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cho, Jaehyung — Washington University
- Study coordinator: Cho, Jaehyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.