Understanding how certain proteins affect airway inflammation and treatment responses in allergic diseases
Patient-Oriented Research Mentorship and Training in Upper Airway Allergic and Inflammatory Diseases
This study is looking at how certain proteins in your body affect inflammation in your airways, especially if you have asthma or chronic sinus issues, to see how new treatments can help you feel better while keeping an eye on any side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001959 on NIH RePORTER |
What this research studies
This research investigates the roles of specific cytokines (IL-4, IL-5, and IL-13) in airway inflammation, particularly in conditions like asthma and chronic rhinosinusitis with nasal polyps. By studying how these proteins function and how their inhibition affects patients, the research aims to uncover the cellular mechanisms behind treatment responses to new biologic drugs. Patients will be monitored for both therapeutic benefits and potential side effects, such as joint pain, to better understand the overall impact of these treatments on their health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic rhinosinusitis with nasal polyps, severe asthma, or aspirin-exacerbated respiratory disease.
Not a fit: Patients with non-allergic airway diseases or those not affected by the specific cytokines being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with allergic airway diseases, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in targeting similar cytokines for treating allergic diseases, indicating a potential for success in this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Laidlaw, Tanya Maria — Brigham and Women's Hospital
- Study coordinator: Laidlaw, Tanya Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.