Understanding how certain proteins affect airway inflammation and treatment responses in allergic diseases
Official title: Patient-Oriented Research Mentorship and Training in Upper Airway Allergic and Inflammatory Diseases
Funded at Brigham and Women's Hospital · NIH-11001959 · Data updated 2026-11-12
This study is looking at how certain proteins in your body affect inflammation in your airways, especially if you have asthma or chronic sinus issues, to see how new treatments can help you feel better while keeping an eye on any side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 19, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $174,031 |
| NIH project number | 5K24AI180296-02 |
| Project ID | NIH-11001959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from chronic rhinosinusitis with nasal polyps, severe asthma, or aspirin-exacerbated respiratory disease.
✕Less likely to help
Patients with non-allergic airway diseases or those not affected by the specific cytokines being studied may not benefit from this research.
What this research studies
This research investigates the roles of specific cytokines (IL-4, IL-5, and IL-13) in airway inflammation, particularly in conditions like asthma and chronic rhinosinusitis with nasal polyps. By studying how these proteins function and how their inhibition affects patients, the research aims to uncover the cellular mechanisms behind treatment responses to new biologic drugs. Patients will be monitored for both therapeutic benefits and potential side effects, such as joint pain, to better understand the overall impact of these treatments on their health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with allergic airway diseases, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in targeting similar cytokines for treating allergic diseases, indicating a potential for success in this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Laidlaw, Tanya Maria — Brigham and Women's Hospital
- Study coordinator: Laidlaw, Tanya Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.