Understanding how certain proteins affect addiction to stimulants and opioids
Transcription Factors in Stimulant and Opioid Action
This study is looking at how certain proteins in the brain affect how stimulants and opioids work, especially in people with addiction, to find new ways to help treat these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11158918 on NIH RePORTER |
What this research studies
This research investigates the role of specific transcription factors in the brain that influence the effects of stimulants and opioids, particularly focusing on the nucleus accumbens and dorsal striatum. By utilizing advanced RNA sequencing techniques, the study aims to identify and characterize these factors in both animal models and humans with substance use disorders. The goal is to uncover new insights into addiction mechanisms and explore potential clinical applications, including the development of small molecule antagonists that could help treat addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of addiction to cocaine or opioids.
Not a fit: Patients who are not struggling with substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals struggling with addiction to stimulants and opioids.
How similar studies have performed: Previous research has shown success in identifying key transcription factors involved in addiction, but this approach aims to uncover novel factors, making it a potentially groundbreaking investigation.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Nestler, Eric J. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Nestler, Eric J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.