Understanding how certain proteins activate immune cells during inflammation
Official title: Molecular regulation of β2 integrin activation in neutrophil adhesion and inflammation
Funded at University of Nevada Reno · NIH-10938563 · Data updated 2026-11-12
This study is looking at how certain proteins help immune cells called neutrophils get activated during inflammation, which is important for understanding heart disease and other related conditions, and it could lead to new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $557,649 |
| NIH project number | 1R01HL174533-01 |
| Project ID | NIH-10938563 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from cardiovascular diseases or conditions associated with chronic inflammation.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by cardiovascular diseases may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that activate β2 integrins in neutrophils, which are crucial for their role in inflammation and cardiovascular disease. By studying how proteins like kindlin-3 and talin-1 interact to regulate these integrins, the research aims to uncover new insights into the inflammatory process. The approach involves using specialized mouse models to visualize and measure integrin activation in real-time, providing a detailed understanding of how immune cells respond to injury. This could lead to new strategies for managing inflammation-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve outcomes for patients with cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding integrin activation and its role in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Wen, Lai — University of Nevada Reno
- Study coordinator: Wen, Lai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.