Understanding how certain plaques form in arteries and their link to heart disease.
A Mechanistic and Translational Research Program Linking Impaired Resolution, Defective Efferocytosis, and Clonal Hematopoiesis to the Formation of Clinically Dangerous Atherosclerotic Plaques
This study is looking into how certain problems in the body, like inflammation and the way we clear out dead cells, can lead to harmful plaque buildup in our arteries, which can cause heart issues, and it aims to find new ways to help keep your heart healthy as you age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11032731 on NIH RePORTER |
What this research studies
This research program investigates the mechanisms behind the formation of dangerous atherosclerotic plaques that can lead to acute cardiovascular disease. It focuses on understanding how inflammation resolution and the clearance of dead cells are impaired, which contributes to the development of these plaques. The program also examines the role of amino acid metabolism and aging-related changes in blood cell production in this process. By exploring these interconnected areas, the research aims to uncover new therapeutic concepts that could improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular disease, particularly those with a history of atherosclerosis or related conditions.
Not a fit: Patients who do not have cardiovascular risk factors or existing atherosclerotic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the formation of harmful plaques in arteries, reducing the risk of heart attacks and strokes.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of atherosclerosis, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Tabas, Ira a — Columbia University Health Sciences
- Study coordinator: Tabas, Ira a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.