Understanding how certain pancreatic lesions evolve into cancer
Interrogation of the Impact of Selection on the Evolution of Human PancreaticCancer Precursor Lesions
['FUNDING_U01'] · JOHNS HOPKINS UNIVERSITY · NIH-11070533
This study is looking at a type of growth in the pancreas called IPMN, which can lead to cancer, to help doctors figure out which ones might turn into cancer and improve how we diagnose and treat them.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11070533 on ClinicalTrials.gov |
What this research studies
This research investigates intraductal papillary mucinous neoplasms (IPMN), which are precursors to pancreatic cancer. By using advanced techniques like DNA and RNA sequencing, along with spatial transcriptomics, the study aims to understand how these lesions develop and evolve over time. The goal is to identify which IPMNs are likely to progress to cancer, enabling better diagnostic tools and treatment strategies. Patients' clinical specimens and organoid models will be analyzed to gain insights into the cellular interactions within the tumor microenvironment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with intraductal papillary mucinous neoplasms (IPMN) or those at high risk for developing pancreatic cancer.
Not a fit: Patients with advanced pancreatic cancer or those without any pancreatic lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods that help identify which pancreatic lesions require treatment, potentially preventing the progression to cancer.
How similar studies have performed: Previous research has shown promise in using genomic and transcriptomic approaches to understand cancer evolution, indicating that this methodology could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOOD, LAURA DELONG — JOHNS HOPKINS UNIVERSITY
- Study coordinator: WOOD, LAURA DELONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers