Understanding how certain organisms eliminate DNA during development
Official title: A genetic model for metazoan programmed DNA elimination
Funded at University of Tennessee Knoxville · NIH-11082484 · Data updated 2026-11-12
This study is exploring how some organisms, like a tiny worm called Oscheius tipulae, get rid of certain parts of their DNA during development, which could help us learn more about genetic diseases and how living things evolve.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $298,847 |
| NIH project number | 5R01GM151551-03 |
| Project ID | NIH-11082484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or those interested in the mechanisms of DNA function and stability.
✕Less likely to help
Patients with conditions unrelated to genetic mechanisms or those not affected by DNA elimination processes may not receive direct benefits from this research.
What this research studies
This research investigates the process of programmed DNA elimination, where significant portions of DNA are selectively removed during the development of certain organisms. By using a genetic model based on the nematode Oscheius tipulae, which is related to C. elegans, the researchers aim to uncover the mechanisms and biological functions behind this phenomenon. The study employs advanced genomic techniques to analyze how and why specific DNA sequences are targeted for elimination, which could provide insights into genome stability and evolution. Patients may benefit from understanding these processes as they relate to genetic diseases and developmental biology.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genome stability and lead to new strategies for addressing genetic disorders.
How similar studies have gone: While the specific approach of studying DNA elimination in metazoans is relatively novel, similar genomic studies have shown promise in understanding genetic mechanisms in other organisms.
Where this research is happening
-
University of Tennessee Knoxville
Knoxville, United States Active
Researchers
- Principal investigator: Wang, Jianbin — University of Tennessee Knoxville
- Study coordinator: Wang, Jianbin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.