Understanding how certain nerve signals cause severe asthma symptoms
Mechanisms of tachykinergic nerve-mediated severe bronchoconstriction and inflammation
This study is looking at how a substance called substance P might make asthma worse, especially for people with a certain type of asthma, by causing tightness in the airways and inflammation, and it hopes to find new ways to help manage these symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11111417 on NIH RePORTER |
What this research studies
This research investigates the role of a neuropeptide called substance P in causing severe bronchoconstriction and inflammation in asthma. By studying both human samples and mouse models, the researchers aim to understand how increased levels of substance P in the airways contribute to asthma symptoms, particularly in individuals with eosinophilic asthma. The study will utilize advanced techniques to explore the mechanisms by which substance P interacts with specific nerve types and immune cells in the airways, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with eosinophilic asthma who experience severe bronchoconstriction.
Not a fit: Patients with asthma that is not eosinophilic or those without significant bronchoconstriction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better control severe asthma symptoms and improve quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuropeptides in asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Drake, Matthew G. — Oregon Health & Science University
- Study coordinator: Drake, Matthew G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.