Understanding how certain nerve signals cause severe asthma symptoms
Official title: Mechanisms of tachykinergic nerve-mediated severe bronchoconstriction and inflammation
Funded at Oregon Health & Science University · NIH-11111417 · Data updated 2026-11-12
This study is looking at how a substance called substance P might make asthma worse, especially for people with a certain type of asthma, by causing tightness in the airways and inflammation, and it hopes to find new ways to help manage these symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 15, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $698,069 |
| NIH project number | 5R01HL171226-02 |
| Project ID | NIH-11111417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic asthma who experience severe bronchoconstriction.
✕Less likely to help
Patients with asthma that is not eosinophilic or those without significant bronchoconstriction may not benefit from this research.
What this research studies
This research investigates the role of a neuropeptide called substance P in causing severe bronchoconstriction and inflammation in asthma. By studying both human samples and mouse models, the researchers aim to understand how increased levels of substance P in the airways contribute to asthma symptoms, particularly in individuals with eosinophilic asthma. The study will utilize advanced techniques to explore the mechanisms by which substance P interacts with specific nerve types and immune cells in the airways, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better control severe asthma symptoms and improve quality of life for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of neuropeptides in asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Drake, Matthew G. — Oregon Health & Science University
- Study coordinator: Drake, Matthew G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.