Understanding how certain mutations lead to skin cancer development
Roles and regulation of transcriptional reprogramming in squamous carcinogenesis
This study is looking at how changes in certain genes can turn normal skin cells into cancer cells, and it aims to find new ways to treat squamous cell carcinoma that could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10895557 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which mutations in specific genes can transform normal skin cells into cancerous cells. By analyzing the gene expression profiles of tumor-propagating cells in squamous cell carcinoma, the study aims to identify key transcription factors that are involved in this transformation. The researchers will explore how these factors interact with the cell's chromatin to activate cancer-related genes. Patients may benefit from insights that could lead to new therapeutic strategies targeting these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with squamous cell carcinoma or those at high risk for developing this type of skin cancer.
Not a fit: Patients with other types of cancer or those without any cancer history may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of precancerous cells into cancerous tumors.
How similar studies have performed: Previous research has shown success in understanding the role of gene expression in cancer development, making this approach promising yet still exploring novel aspects.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Schober, Markus — New York University School of Medicine
- Study coordinator: Schober, Markus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.