Understanding how certain mutations in mitochondrial DNA affect cancer
Official title: Defining the function of Complex I truncating mutations in cancer
Funded at Sloan-Kettering Inst Can Research · NIH-11001531 · Data updated 2026-11-12
This study is looking at how certain changes in mitochondrial DNA affect colorectal cancer cells, using special technology to see how these changes influence the cancer's behavior, which could help find new ways to treat patients like you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $571,533 |
| NIH project number | 5R37CA276200-03 |
| Project ID | NIH-11001531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer or other cancers associated with mitochondrial mutations.
✕Less likely to help
Patients with cancers not linked to mitochondrial mutations may not receive direct benefits from this research.
What this research studies
This research investigates the impact of truncating mutations in mitochondrial DNA on cancer cells, particularly focusing on colorectal cancer. By utilizing advanced mtDNA-editing technology, the team aims to introduce specific mutations into cancer cell lines to observe their effects on cellular function and metabolism. This approach allows for a detailed examination of how these mutations contribute to cancer progression and may reveal new therapeutic targets. Patients may benefit from insights gained about the role of mitochondrial mutations in their cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting mitochondrial mutations in cancer treatment.
How similar studies have gone: While the approach of editing mitochondrial DNA is relatively novel, similar methodologies have shown promise in other areas of cancer research.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Reznik, Eduard — Sloan-Kettering Inst Can Research
- Study coordinator: Reznik, Eduard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.