Understanding how certain mutations in G proteins contribute to cancer
Regulation of Mutationally Activated Gq/11
This study is looking at how certain changes in G proteins can cause cancers like uveal melanoma, with the goal of finding new ways to treat these conditions, so patients can have better options in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10764261 on NIH RePORTER |
What this research studies
This research investigates the role of specific mutations in G proteins that can lead to cancer, particularly focusing on uveal melanoma and other vascular tumors. By studying how these mutations affect cellular signaling, the research aims to uncover new mechanisms that could be targeted for treatment. The approach involves examining the behavior of mutated G proteins and their impact on cell function and movement. Patients may benefit from insights that could lead to new therapeutic strategies for cancers associated with these mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with uveal melanoma or other vascular tumors linked to G protein mutations.
Not a fit: Patients with cancers not associated with G protein mutations or those without the specific mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for cancers driven by specific G protein mutations.
How similar studies have performed: Other research has shown promising results in targeting G protein mutations, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wedegaertner, Philip B — Thomas Jefferson University
- Study coordinator: Wedegaertner, Philip B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.