Understanding how certain mutations affect colon cancer development
Official title: Mechanisms of Serrated Colon Tumor Suppression
Funded at Rutgers, the State Univ of N.j. · NIH-11086702 · Data updated 2026-11-12
This study is looking at how certain changes in genes can lead to colon cancer by focusing on the early stages in colon stem cells, which could help us find better ways to spot and prevent this type of cancer in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | June 8, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $392,500 |
| NIH project number | 5R01CA190558-08 |
| Project ID | NIH-11086702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of colon cancer or those identified as having genetic predispositions to Serrated tumors.
✕Less likely to help
Patients with non-Serrated forms of colon cancer or those without any genetic risk factors for colon cancer may not benefit from this research.
What this research studies
This research investigates the early mechanisms of colon cancer formation, specifically focusing on the effects of BRAF mutations in colon stem cells. By studying these mutations in a controlled environment, researchers aim to uncover how they influence tumor development and differentiation. The project will utilize advanced genetic mouse models to analyze the role of specific transcription factors and their impact on cancer susceptibility. This work could lead to improved strategies for early detection and prevention of Serrated colon tumors.
Why it matters
Potential benefit: If successful, this research could lead to better methods for detecting and preventing Serrated colon cancer in patients.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors involved in colon cancer, making this approach a continuation of established findings.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Verzi, Michael P. — Rutgers, the State Univ of N.j.
- Study coordinator: Verzi, Michael P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.