Understanding how certain molecules related to oxidative stress affect health
Official title: Comprehensive Determination of Isoprostanoid Metabolism
Funded at Vanderbilt University Medical Center · NIH-10809491 · Data updated 2026-11-12
This study is looking at how oxidative stress affects aging and diseases like COVID-19 by measuring certain markers in the body, which could help us understand these conditions better and find new ways to treat them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 23, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $478,765 |
| NIH project number | 1R21AG081823-01A1 |
| Project ID | NIH-10809491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing age-related diseases such as cardiovascular issues, neurodegeneration, or those affected by COVID-19.
✕Less likely to help
Patients with acute conditions unrelated to oxidative stress or age-related diseases may not benefit from this research.
What this research studies
This research investigates the role of oxidative stress in aging and various diseases, including COVID-19, by focusing on specific biomarkers known as F2-Isoprostanes. These biomarkers are formed from the oxidation of lipids and can indicate the level of oxidative stress in the body. The study aims to quantify not only F2-Isoprostanes but also their metabolites, which may provide a more accurate reflection of oxidative stress in different biological contexts. By identifying these biomarkers, the research seeks to enhance our understanding of disease mechanisms and improve potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for age-related diseases and conditions linked to oxidative stress.
How similar studies have gone: Previous research has shown success in using F2-Isoprostanes as biomarkers in clinical trials, indicating a promising avenue for this approach.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Milne, Ginger Lohr — Vanderbilt University Medical Center
- Study coordinator: Milne, Ginger Lohr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.