Understanding how certain molecules related to oxidative stress affect health
Comprehensive Determination of Isoprostanoid Metabolism
['FUNDING_R21'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10809491
This study is looking at how oxidative stress affects aging and diseases like COVID-19 by measuring certain markers in the body, which could help us understand these conditions better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10809491 on ClinicalTrials.gov |
What this research studies
This research investigates the role of oxidative stress in aging and various diseases, including COVID-19, by focusing on specific biomarkers known as F2-Isoprostanes. These biomarkers are formed from the oxidation of lipids and can indicate the level of oxidative stress in the body. The study aims to quantify not only F2-Isoprostanes but also their metabolites, which may provide a more accurate reflection of oxidative stress in different biological contexts. By identifying these biomarkers, the research seeks to enhance our understanding of disease mechanisms and improve potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related diseases such as cardiovascular issues, neurodegeneration, or those affected by COVID-19.
Not a fit: Patients with acute conditions unrelated to oxidative stress or age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for age-related diseases and conditions linked to oxidative stress.
How similar studies have performed: Previous research has shown success in using F2-Isoprostanes as biomarkers in clinical trials, indicating a promising avenue for this approach.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILNE, GINGER LOHR — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: MILNE, GINGER LOHR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.