Understanding how certain molecules in ovarian fluid can improve egg freezing techniques
Investigating the physiological significance of follicular extracellular vesicle miRNAs: From gonadotropin control of biogenesis to application in oocyte vitrification
This study is looking at how tiny particles in the fluid around cat eggs might help improve the freezing process for eggs, which could lead to better results in fertility treatments for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Smithsonian Institution NIH-funded |
| Lab location | 1 site (Washington, DC, UNITED STATES) |
| Project ID | NIH-10801855 on NIH RePORTER |
What this research studies
This research investigates the role of extracellular vesicles and their microRNAs in ovarian follicular fluid, focusing on how they can enhance the effectiveness of oocyte cryopreservation. By using the domestic cat as a model, the study aims to understand how gonadotropin stimulation affects the composition of these vesicles and their potential to improve egg viability after freezing. The researchers will employ advanced microfluidic technology to simulate hormonal exposure on ovarian cells, which may lead to better outcomes in assisted reproductive technologies for humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are women considering oocyte cryopreservation, particularly those of advanced maternal age.
Not a fit: Patients who are not seeking fertility preservation or are not undergoing assisted reproductive technologies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for egg freezing, potentially increasing live birth rates for women using assisted reproductive technologies.
How similar studies have performed: Previous studies have shown promise in using extracellular vesicles to enhance reproductive outcomes, indicating that this approach may be effective.
Where this research is happening
Washington, DC, UNITED STATES
- Smithsonian Institution — Washington, DC, United States (Active)
Researchers
- Principal investigator: Nagashima, Jennifer — Smithsonian Institution
- Study coordinator: Nagashima, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.