Understanding how certain molecules affect hormone signaling in the body
Official title: The role of cell surface glycosaminoglycans (GAGs) in PTHrP bias signaling
Funded at University of Pittsburgh at Pittsburgh · NIH-11056679 · Data updated 2026-11-12
This study is looking at how certain sugars in the body, called glycosaminoglycans, work with a protein that helps control bone health and calcium levels, which could help us understand more about how these processes affect our overall health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31DK136222-02 |
| Project ID | NIH-11056679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting bone formation or calcium metabolism, such as osteoporosis or certain cancers.
✕Less likely to help
Patients with unrelated hormonal disorders or those not experiencing issues with bone health or calcium levels may not benefit from this research.
What this research studies
This research investigates the role of glycosaminoglycans (GAGs) in the signaling process of parathyroid hormone-related protein (PTHrP), which is crucial for various bodily functions including bone formation and calcium transport. The study aims to explore how GAGs interact with PTHrP to influence its signaling through specific receptors. By using advanced imaging techniques and biophysical methods, researchers will analyze the binding properties and cellular mechanisms involved in this process. This could lead to a better understanding of how these interactions affect health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into hormone signaling that may improve treatments for conditions related to bone health and calcium regulation.
How similar studies have gone: While the specific role of GAGs in PTHrP signaling is less explored, similar research has shown promising results in understanding hormone interactions and their implications for health.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Savransky, Sofya — University of Pittsburgh at Pittsburgh
- Study coordinator: Savransky, Sofya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.