Understanding how certain molecules affect blood clot formation and healing
Role of glycosaminoglycans (GAGs) in deep vein thrombus formation and resolution
This study is looking at how certain substances in our blood vessels might help us understand and improve treatments for deep vein thrombosis (DVT), which can cause serious health issues, so that patients can have better ways to prevent and manage this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10906834 on NIH RePORTER |
What this research studies
This research investigates the role of glycosaminoglycans (GAGs) in the formation and resolution of deep vein thrombosis (DVT), a condition that can lead to serious complications. The study focuses on how the endothelial glycocalyx, a protective layer on blood vessel cells, influences blood clotting processes. By examining the interactions between GAGs and key components of the coagulation system, the research aims to uncover mechanisms that could lead to improved treatments for DVT and its long-term effects. Patients may benefit from insights that could lead to better prevention and management strategies for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for deep vein thrombosis, such as those with a history of blood clots or certain medical conditions that predispose them to clotting.
Not a fit: Patients who do not have risk factors for DVT or those with conditions unrelated to blood clotting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that reduce the incidence of DVT and improve recovery outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of endothelial glycocalyx in vascular health, suggesting that this approach may yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mathews, Rick — Oregon Health & Science University
- Study coordinator: Mathews, Rick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.