Understanding how certain molecules activate a key protein involved in cancer signaling
Mechanisms of Smoothened Activation in Hedgehog Signaling
This study is looking at how certain molecules can activate a protein that helps send signals in our cells, which is important for understanding how some cancers, like basal cell carcinoma, develop, and it could help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10979156 on NIH RePORTER |
What this research studies
This research investigates the Hedgehog signaling pathway, which plays a crucial role in human development and is linked to various cancers, including basal cell carcinoma. The study aims to uncover how specific molecules called sterols activate a protein known as Smoothened (SMO), which is essential for transmitting signals within cells. By employing advanced techniques like X-ray crystallography and cryo-electron microscopy, researchers will explore the binding sites of sterols on SMO and how this interaction influences cancer signaling. This work could lead to a better understanding of cancer mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with basal cell carcinoma or related cancers influenced by the Hedgehog signaling pathway.
Not a fit: Patients with cancers unrelated to the Hedgehog signaling pathway may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into cancer treatment by identifying novel targets for drug development.
How similar studies have performed: Previous research has shown promising results in targeting the Hedgehog signaling pathway for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Manglik, Aashish — University of California, San Francisco
- Study coordinator: Manglik, Aashish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.