Understanding how certain molecular pathways affect glioblastoma growth
Defining the molecular mechanisms regulating the hexosamine-N-glycosylation pathway in glioblastoma
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10650291
This study is looking at how certain processes in cells help glioblastoma, a tough type of brain cancer, grow, with the hope of finding new ways to treat it that could help patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10650291 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that regulate the hexosamine-N-glycosylation pathway in glioblastoma, a type of aggressive brain tumor. By examining how specific enzymes and metabolic pathways contribute to tumor growth, the research aims to uncover new targets for treatment. The approach includes laboratory experiments to analyze the expression of key enzymes involved in this pathway and their impact on glioblastoma cell metabolism. Patients may benefit from insights that could lead to more effective therapies for this challenging cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who are 21 years or older.
Not a fit: Patients with other types of brain tumors or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve survival rates for glioblastoma patients.
How similar studies have performed: While the specific focus on the hexosamine-N-glycosylation pathway in glioblastoma is novel, similar metabolic pathway investigations have shown promise in other cancer types.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUO, DELIANG — OHIO STATE UNIVERSITY
- Study coordinator: GUO, DELIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer