Understanding how certain microRNAs affect melanoma growth and diagnosis
Nevus associated microRNAs as mediators of BRAF-induced growth arrest and biomarkers of melanoma progression
This study is looking at how certain tiny molecules in our cells can help stop harmless moles from turning into melanoma, especially in people with a common mutation, and aims to create better ways to diagnose and prevent this skin cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10893435 on NIH RePORTER |
What this research studies
This research investigates the role of specific microRNAs in the development of melanoma, particularly focusing on the BRAFV600E mutation that is common in many cases. The team aims to uncover how these microRNAs can prevent benign moles from transforming into malignant melanoma and to develop early diagnostic tools and prevention strategies. By using advanced techniques like CRISPR and non-invasive assays, they will analyze the behavior of these microRNAs in both benign and malignant skin cells. Patients may benefit from improved diagnostic accuracy and potential preventive measures against melanoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with benign moles or those at high risk for developing melanoma due to genetic factors.
Not a fit: Patients who already have advanced melanoma or those without any skin lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better early diagnosis and prevention strategies for melanoma, potentially saving lives.
How similar studies have performed: Previous research has shown promise in using microRNA signatures for cancer diagnosis, indicating that this approach may be effective.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Judson-Torres, Robert Laird — University of Utah
- Study coordinator: Judson-Torres, Robert Laird
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.