Understanding how certain mice respond to Lyme disease
Genetic architecture of host response to tickborne disease in Peromyscus leucopus
This study is looking at how the genes of white-footed deermice, which can carry Lyme disease, affect how they get infected and fight off the bacteria that cause it, helping us understand more about how Lyme disease spreads.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10900595 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence how the white-footed deermouse, a key reservoir for Lyme disease, responds to infection by the bacterium Borreliella burgdorferi. By studying these mice, researchers aim to identify genetic traits that affect the prevalence of infection and the immune response, including antibody production and tissue inflammation. The approach involves advanced genetic techniques and monitoring of infection dynamics in the mice over time. This work could provide insights into the mechanisms of Lyme disease transmission and host response.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals interested in the genetic basis of infectious diseases, particularly those affected by Lyme disease.
Not a fit: Patients who are not affected by Lyme disease or do not have a specific interest in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of Lyme disease in humans by identifying genetic factors that influence disease transmission.
How similar studies have performed: Other research has shown success in using genetic models to understand infectious diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Long, Anthony Douglas — University of California-Irvine
- Study coordinator: Long, Anthony Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.