Understanding how certain medications lower blood pressure in heart failure patients
Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition
This study is looking at how a special heart medication called LCZ696 helps lower blood pressure in people with heart failure, and it aims to understand why some patients might feel lightheaded while taking it, so we can make treatment better for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10886498 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which a combination medication, LCZ696, helps lower blood pressure in patients with heart failure. It focuses on how this medication, which includes an angiotensin receptor blocker and a neprilysin inhibitor, affects various hormones and peptides in the body that regulate blood pressure. By studying these interactions, the research aims to clarify why some patients experience hypotension when using this treatment, potentially leading to improved clinical guidelines and patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure who are being considered for treatment with LCZ696.
Not a fit: Patients who do not have heart failure or those who are not candidates for treatment with LCZ696 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of blood pressure in heart failure patients, improving their overall health and quality of life.
How similar studies have performed: Previous studies have shown that similar approaches to understanding medication mechanisms in heart failure have led to significant advancements in treatment options.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Brown, Nancy J. — Yale University
- Study coordinator: Brown, Nancy J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.