Understanding how certain lymphomas develop in B cells
Official title: Modeling Marginal Zone Lymphomagenesis
Funded at Virginia Commonwealth University · NIH-10947653 · Data updated 2026-11-12
This study is looking at a type of B-cell cancer called marginal zone lymphoma to better understand how it develops, using special mouse models to explore certain pathways in B cells, which could help create new treatments that might benefit patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 5, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $399,187 |
| NIH project number | 1R21CA270930-01A1 |
| Project ID | NIH-10947653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with marginal zone lymphoma or related B-cell malignancies.
✕Less likely to help
Patients with other types of cancers not related to B-cell malignancies may not receive direct benefits from this research.
What this research studies
This research focuses on marginal zone lymphomas, a type of B-cell cancer, and aims to create better models to study its development. By investigating the role of specific signaling pathways, particularly the PI3K/AKT/mTOR pathway, the researchers hope to understand how these cancers form and progress. The study will utilize genetically engineered mouse models to explore the effects of these pathways on B cells, which could lead to more effective treatments. Patients may benefit from the findings as they could inform new therapeutic strategies for this common type of lymphoma.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with marginal zone lymphomas.
How similar studies have gone: Previous research has shown promising results using similar approaches to target the PI3K/AKT/mTOR pathway in B-cell malignancies.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Yazbeck, Victor — Virginia Commonwealth University
- Study coordinator: Yazbeck, Victor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.