Understanding how certain lung cells repair themselves after injury
Official title: Epigenetic signatures driving metaplastic repair mechanisms in human alveolar type II cells
Funded at University of California, San Francisco · NIH-10993817 · Data updated 2026-11-12
This study is looking at how certain lung cells can heal and change into other types of cells after injury, especially in people with lung diseases, to find new ways to help improve lung health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $84,364 |
| NIH project number | 1F32HL175915-01 |
| Project ID | NIH-10993817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing or at risk for fibrotic lung diseases.
✕Less likely to help
Patients with non-respiratory conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the mechanisms by which alveolar type II (AT2) cells in the lungs can repair and regenerate after injury. It focuses on how these cells can transform into other cell types to restore normal lung function, particularly in the context of fibrotic lung diseases. The study employs advanced techniques like ATAC sequencing to analyze the epigenetic changes that guide these repair processes. By understanding these cellular behaviors, the research aims to uncover potential therapeutic targets for improving lung health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung repair mechanisms in patients with fibrotic lung diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular differentiation in lung tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Iantorno, Stefano Azelio — University of California, San Francisco
- Study coordinator: Iantorno, Stefano Azelio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.