Understanding how certain lung cells help maintain immune balance in the lungs.
Lung IDO-1+ TNFR2+ cDC2 subset in control of lung mucosal tolerance: Mechanism and Application
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10796774
This study is looking at how certain lung cells help keep your lungs healthy and prevent issues like asthma, and it aims to find new treatments using a medicine called interferon beta to improve lung function for people with chronic lung problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10796774 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific lung cells in controlling immune responses to maintain lung health and prevent chronic inflammatory diseases like asthma. The team will explore how these cells interact with immune signals and develop a treatment approach using interferon beta to restore proper lung function. By studying the mechanisms behind lung mucosal tolerance, the research aims to identify new therapeutic strategies that could lead to more effective treatments for patients with chronic lung conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory lung diseases, particularly asthma.
Not a fit: Patients with acute respiratory infections or those without chronic lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that not only manage asthma symptoms but also repair the underlying causes of the disease.
How similar studies have performed: Previous research has shown promise in targeting immune mechanisms in the lungs, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIN, LEI — UNIVERSITY OF FLORIDA
- Study coordinator: JIN, LEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.