Understanding how certain liver cells influence liver cancer development
Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC
This study is looking at how certain liver cells can both help and hinder the growth of liver cancer in people with a condition called non-alcoholic steatohepatitis (NASH), with the hope of finding new ways to treat liver disease and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10872260 on NIH RePORTER |
What this research studies
This research investigates the dual roles of hepatic stellate cells in the development of hepatocellular carcinoma (HCC), particularly in patients with non-alcoholic steatohepatitis (NASH). By examining how these liver cells can both promote and suppress tumor growth, the study aims to uncover the mechanisms behind liver cancer progression. The research utilizes genetic approaches to analyze the behavior of these cells in fibrotic livers, which are common in patients with advanced liver disease. Patients may benefit from insights that could lead to new therapeutic strategies targeting liver fibrosis and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with non-alcoholic steatohepatitis (NASH) or those at risk for developing hepatocellular carcinoma due to liver fibrosis.
Not a fit: Patients with liver cancer not associated with NASH or those without significant liver fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver cancer and better management of liver diseases associated with obesity and NASH.
How similar studies have performed: Previous research has shown promising results in understanding the role of liver cells in cancer development, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Schwabe, Robert F. — Columbia University Health Sciences
- Study coordinator: Schwabe, Robert F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.