Understanding how certain lipoproteins contribute to heart disease
Official title: Biogenesis and Catabolism of Atherogenic Lipoproteins
Funded at NYU Long Island School of Medicine · NIH-11064044 · Data updated 2026-11-12
This study is looking at how certain fats in your blood can lead to heart problems, and it's trying to find new ways to lower those harmful fats to keep your arteries healthy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $2,221,131 |
| NIH project number | 5P01HL160470-03 |
| Project ID | NIH-11064044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cardiovascular disease, particularly those with elevated levels of triglycerides or atherogenic lipoproteins.
✕Less likely to help
Patients who do not have cardiovascular disease risk factors or those with established heart disease may not benefit from this research.
What this research studies
This research investigates the production and breakdown of atherogenic lipoproteins, which are linked to cardiovascular disease (CVD). It aims to identify new biological processes and factors that regulate the levels of triglycerides and cholesterol in the body. By studying both human data and new animal models, the research seeks to uncover unique targets that could help reduce harmful lipoproteins and their impact on artery health. The approach combines basic cellular mechanisms with translational insights to improve understanding and treatment of CVD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for reducing the risk of cardiovascular disease by targeting specific lipoproteins.
How similar studies have gone: Previous research has shown promise in targeting lipoprotein metabolism to reduce cardiovascular risk, indicating that this approach may lead to significant advancements.
Where this research is happening
-
NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Hussain, M Mahmood — NYU Long Island School of Medicine
- Study coordinator: Hussain, M Mahmood
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.