Understanding how certain leukemia cells resist treatment
Elucidating Critical Dependencies Underlying Therapeutic Evasion in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-10995045
This study is looking at a tough type of leukemia called Ph-like ALL in kids, and it aims to understand how these cancer cells avoid treatment so that we can create better, more targeted therapies to help them.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10995045 on ClinicalTrials.gov |
What this research studies
This research focuses on Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL), a type of leukemia that is particularly challenging to treat. The project aims to uncover the critical biological dependencies that allow these cancer cells to evade therapies. By utilizing advanced techniques in genomics and bioinformatics, the research will explore how these cells function and respond to treatment, with the goal of developing more effective precision medicine therapies for affected children. The research will be conducted under the guidance of experienced mentors and will involve collaboration with a team of renowned scientists.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with Philadelphia chromosome-like acute lymphoblastic leukemia.
Not a fit: Patients with other types of leukemia or those who are not within the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for children suffering from difficult-to-treat leukemias.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in leukemia, indicating that this approach could yield significant advancements.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DING, YANG-YANG — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DING, YANG-YANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.