Understanding how certain leukemia cells resist treatment
Official title: Elucidating Critical Dependencies Underlying Therapeutic Evasion in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Funded at Johns Hopkins University · NIH-10995045 · Data updated 2026-11-12
This study is looking at a tough type of leukemia called Ph-like ALL in kids, and it aims to understand how these cancer cells avoid treatment so that we can create better, more targeted therapies to help them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 5, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $184,541 |
| NIH project number | 5K08CA273531-03 |
| Project ID | NIH-10995045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with Philadelphia chromosome-like acute lymphoblastic leukemia.
✕Less likely to help
Patients with other types of leukemia or those who are not within the pediatric age range may not benefit from this research.
What this research studies
This research focuses on Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL), a type of leukemia that is particularly challenging to treat. The project aims to uncover the critical biological dependencies that allow these cancer cells to evade therapies. By utilizing advanced techniques in genomics and bioinformatics, the research will explore how these cells function and respond to treatment, with the goal of developing more effective precision medicine therapies for affected children. The research will be conducted under the guidance of experienced mentors and will involve collaboration with a team of renowned scientists.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for children suffering from difficult-to-treat leukemias.
How similar studies have gone: Previous research has shown promise in targeting similar pathways in leukemia, indicating that this approach could yield significant advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Ding, Yang-Yang — Johns Hopkins University
- Study coordinator: Ding, Yang-Yang
Related research
Other NIH-funded projects on the same topics.
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Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
-
Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
-
Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
-
Combinatorial targeting for high-risk B-cell ALL treatment
A research effort at West Virginia University is exploring a combination therapy for adult B-cell acute lymphoblastic leukemia using targeted gene silencing and a small-molecule compound to improve treatment in patients.
-
Understanding why Latino children have a higher risk of childhood ALL
This project looks at why Latino children are more likely to develop acute lymphoblastic leukemia and whether genetic ancestry plays a role, with the goal of improving prevention and outcomes.
-
Targeting obesity to improve survival for children with ALL
A new approach explores whether reducing obesity-related factors can make chemotherapy work better for kids with acute lymphoblastic leukemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.