Understanding how certain ion channels work in the body
Structure and Function of Pentameric Ligand-gated Ion Channels
This study is looking at how certain channels in our cells work, which are important for things like feeling pain and moving our bodies, to find new ways to help treat issues like addiction and chronic pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11010557 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control the function of pentameric ligand-gated ion channels, which play a vital role in various physiological processes such as pain transmission and motor coordination. By using advanced techniques like cryo-electron microscopy and molecular dynamics simulations, the research aims to uncover how these channels are regulated and how they can be targeted for therapeutic purposes. The findings could lead to better understanding and treatment options for conditions like addiction and chronic pain, which are linked to dysfunctional ion channels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from neurological disorders, chronic pain, or addiction.
Not a fit: Patients with conditions unrelated to the function of pentameric ligand-gated ion channels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for neurological disorders, addiction, and chronic pain.
How similar studies have performed: Previous research has shown promising results in understanding similar ion channels, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Chakrapani, Sudha — Case Western Reserve University
- Study coordinator: Chakrapani, Sudha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.