Understanding how certain ion channels affect calcium signaling in cells
Molecular physiology of intracellular InsP3R and MCU ion channels
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11078768
This study is looking at how certain channels in our cells help control calcium levels, which is important for keeping our cells healthy and energized, and it could help us understand diseases like Alzheimer's and cancer better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11078768 on ClinicalTrials.gov |
What this research studies
This research investigates the role of inositol trisphosphate receptors (InsP3R) and mitochondrial calcium uptake in regulating calcium levels within cells. By using advanced techniques like single-channel patch-clamp electrophysiology, the study aims to uncover how these ion channels function and how they influence cellular metabolism and energy production. The findings could provide insights into the mechanisms underlying various diseases, including Alzheimer's disease and cancer, by examining how calcium signaling affects cell health and function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk for neurodegenerative conditions.
Not a fit: Patients with conditions unrelated to calcium signaling or those not diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like Alzheimer's disease and cancer by targeting calcium signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOSKETT, JAMES KEVIN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: FOSKETT, JAMES KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease