Understanding how certain intestinal cells can regenerate after injury
Official title: Paneth cell plasticity and regeneration
Funded at University of Pennsylvania · NIH-10994454 · Data updated 2026-11-12
This study is looking at how certain cells in your gut, called Paneth cells, can heal and regenerate after injury, which could help improve treatments for inflammatory bowel disease (IBD) and make it easier for patients like you to recover.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31DK141082-01 |
| Project ID | NIH-10994454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who experience chronic inflammation and impaired intestinal healing.
✕Less likely to help
Patients without inflammatory bowel disease or those whose conditions do not involve epithelial healing issues may not benefit from this research.
What this research studies
This research investigates the healing process of intestinal epithelial cells, particularly focusing on Paneth cells, which play a crucial role in replenishing damaged cells in the digestive tract. By examining how these cells can de-differentiate and regenerate after injury, the study aims to uncover mechanisms that could lead to improved treatments for inflammatory bowel disease (IBD). The approach involves analyzing the role of autophagy in cell recovery and the potential for developing novel therapies that address epithelial repair defects rather than just targeting the immune response. Patients with IBD may find this research particularly relevant as it seeks to enhance understanding of their condition and improve healing processes.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with inflammatory bowel disease by promoting better intestinal healing.
How similar studies have gone: Previous research has shown promising results in understanding cell regeneration in similar contexts, indicating potential for success in this area.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Katada, Kay — University of Pennsylvania
- Study coordinator: Katada, Kay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.