Understanding how certain immune structures help fight cancer
Official title: ROLES AND MECHANISMS OF TERTIARY LYMPHOID STRUCTURES IN ANTI-TUMOR IMMUNITY
Funded at Ohio State University · NIH-11005311 · Data updated 2026-11-12
This study is looking at how certain immune structures in tumors can help the body fight pancreatic cancer better, and it aims to find ways to improve treatment for patients by understanding how these structures work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $425,880 |
| NIH project number | 5R01CA286017-02 |
| Project ID | NIH-11005311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing surgical resection.
✕Less likely to help
Patients with early-stage pancreatic cancer who do not exhibit the formation of tertiary lymphoid structures may not benefit from this research.
What this research studies
This research investigates the role of tertiary lymphoid structures (TLS) in enhancing the immune response against pancreatic cancer. By examining how these structures form in tumors and their impact on T cell immunity, the study aims to uncover mechanisms that could improve patient outcomes. The researchers will analyze both human and mouse models to determine how TLS contribute to the development of specific T cell types that are crucial for effective anti-tumor immunity. This could lead to new strategies for boosting the immune response in cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments that enhance the body's immune response against tumors.
How similar studies have gone: Other research has shown promising results regarding the role of tertiary lymphoid structures in cancer immunity, indicating that this approach has potential for significant findings.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gunderson, Andrew — Ohio State University
- Study coordinator: Gunderson, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.