Understanding how certain immune responses protect against tuberculosis without interferon gamma.
Mechanisms of IFNg-independent T cell and B cell-mediated protection in TB.
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10882693
This study is looking at why some people can stay healthy and not get tuberculosis (TB) even after being around it a lot, and it hopes to find out how their immune system works differently to help protect them, which could lead to better ways to prevent and treat TB.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10882693 on ClinicalTrials.gov |
What this research studies
This research investigates how some individuals can resist tuberculosis (TB) infection despite significant exposure to the bacteria Mycobacterium tuberculosis. It focuses on a unique group of people who remain negative for the interferon gamma release assay (IGRA) even after being exposed to TB, suggesting they have developed a different type of immune response. By studying the immune mechanisms in these 'resisters,' the research aims to uncover how T cells and B cells work together to provide protection against TB. This could lead to new insights into TB immunity and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been exposed to tuberculosis but remain IGRA negative, indicating a strong immune response.
Not a fit: Patients who have active tuberculosis or those who are IGRA positive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating tuberculosis, particularly for those at high risk.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to tuberculosis, but this specific approach focusing on IFNg-independent mechanisms is relatively novel.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SALGAME, PADMINI — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: SALGAME, PADMINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.