Understanding how certain immune cells survive and compete for resources
CD138 Regulates Competition of Antibody Secreting Cells for Survival
This study is looking at how certain long-lasting immune cells help keep our bodies protected after vaccinations, especially in older adults, and aims to find out how we can make vaccines work better so that we don’t need as many booster shots.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11177765 on NIH RePORTER |
What this research studies
This research investigates the survival mechanisms of long-lived antibody-secreting cells (LLASCs) that are crucial for maintaining effective immune responses after vaccinations. It focuses on how these cells interact within their environment, or 'niche', and the factors that influence their longevity and competition for survival. By studying the role of specific cytokines and the organization of the niche, the research aims to uncover why some vaccines require more frequent boosters, especially in older adults. The findings could lead to improved vaccine strategies that enhance immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may have weakened immune responses and require vaccinations.
Not a fit: Patients who are not older adults or those with robust immune systems may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that require fewer booster shots, particularly benefiting older adults.
How similar studies have performed: Other research has shown promising results in understanding immune cell dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Fooksman, David R — Albert Einstein College of Medicine
- Study coordinator: Fooksman, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.