Understanding how certain immune cells regulate inflammation in the lungs
Transcriptional and metabolomic regulation of IL-10 in pulmonary ILC2s
This study is looking at how certain immune cells in the lungs help reduce inflammation in allergic conditions like asthma, and it aims to find new ways to improve treatments for people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10894182 on NIH RePORTER |
What this research studies
This research investigates the role of a specific type of immune cell, known as ILC2s, in the lungs and how they produce IL-10, a cytokine that helps reduce inflammation associated with allergic diseases like asthma. The researchers will use advanced techniques to explore the molecular mechanisms that control IL-10 production, including the study of transcription factors and metabolic pathways. By conducting experiments in both acute and chronic models of allergic airway inflammation, they aim to identify potential targets for new therapies that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic asthma or related allergic diseases.
Not a fit: Patients with non-allergic asthma or those without a history of allergic reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce inflammation and improve symptoms for patients with allergic asthma.
How similar studies have performed: Other research has shown success in targeting IL-10 production in various allergic disease models, indicating a promising avenue for therapeutic development.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Akbari, Omid — University of Southern California
- Study coordinator: Akbari, Omid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.